Associate Scientist/Scientist, In Vivo Pharmacology (industry experience required)

Job Description

Job Description

Septerna is a biotechnology company based in South San Francisco, CA on a mission to develop life-changing medicines for patients with the vision to become the industry-leading G protein-coupled receptor (GPCR)-focused drug discovery company. The company's Native Complex Platform™ recapitulates GPCRs with their native structure, function, and dynamics outside of the cellular context. This approach enables novel access to modern structural and screening technologies used in industrial-scale drug discovery for the entire class of GPCRs. Septerna has an emerging pipeline of GPCR-targeted small molecule programs with potential for growth to target many GPCRs that have been undruggable and unexploited to date.

We are excited to expand our multidisciplinary team of individuals focused on creating revolutionary medicines to address the unmet needs of patients. At Septerna we strive to embrace diversity of thought, expertise, and background through collaboration. To join our ambitious team, be prepared to bring your real self to work every day; grow and learn from a talented team of drug hunters, scientists, and business professionals; and contribute your passion, creativity, and energy to accomplish our mission. We share a fearless pursuit of ground-breaking innovations and cultivate an environment where our employees succeed by learning from each other and working as a team.

We are committed to the development of meaningful therapeutics for patients with indications of high unmet need. This is a tremendous opportunity to work with talented individuals on the frontlines of therapeutic discovery and development. You will directly help move therapies through preclinical research, positioning them for success in the clinic. The successful candidate will add their passion, unique talents, and expertise to a dynamic team motivated to discover new disease-modifying therapeutics for patients in a fast-paced environment.

For more information see: www.septerna.com.

THE ROLE

The Associate scientist/Scientist will primarily be responsible for the development and conduct of in vivo, ex vivo, as well as in vitro studies in in vivo Pharmacology to support the advancement of Septerna's small molecule drug discovery pipeline. They will help develop preclinical models, generate robust data to support therapeutic development and contribute to the understanding of therapeutic mechanism of action. The successful candidate will add their passion, unique talents, and expertise to a dynamic team on the frontlines of innovative therapeutic development.

The position is based in South San Francisco, CA. Title and compensation commensurate with experience.

Key Responsibilities:

• Perform surgical procedures in rodents
• Design and execute in vivo and in vitro studies in rodents
• Generate, analyze, document, and help interpret data to establish functional PK/PD relationships
• Contribute to the interpretation of experimental results in a broader biological and pharmacological context to progress our understanding of target biology and therapeutic hypothesis
• Help in authoring in vivo pharmacology study designs, protocols, and reports to support regulatory filings
• Follow all company policies/practices, and maintain accurate records and notebooks

Required education, skills and experience

• BSc or MSc in Pharmacology, Toxicology, or related biological science
• At least 10 (or 8 years with MSc) direct experience with generating complex surgical models in rodents in academia or the biotechnology and pharmaceutical industries
• Ability to collaborate in writing protocols and trouble-shooting biological experiments
• Detail-oriented and organized, with strong interpersonal skills for clear and effective communication
• Ability to proactively engage and collaborate with colleagues to integrate in vivo findings with in vitro pharmacology studies

Preferred skills and experience

• Experience working with rodent models of bone, kidney, and/or endocrine organs
• Previous work on therapeutic discovery and development programs
• Experience working with vendors and CROs to execute studies, analyze data, and generate reports

The anticipated salary range for candidates who will work in South San Francisco, CA is $100,000 - $125,000. Individual pay may vary based on additional factors, including, and without limitation, job-related skills, experience, work location and relevant education or training. Septerna's compensation package also includes benefits, stock options, and annual target bonus for full-time positions.

We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.

Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited. We are an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status. Septerna participates in the E-Verify program. California Consumer Privacy Act Privacy Notice For Job Applicants. If you are a California resident, click here for our CCPA Notice.